In vitro Investigation of Rutin-Loaded PLGA Nanoparticles on Leishmania infantum Promastigotes

Leishmaniasis is a group of illnesses occasioned Leishmania (L.) parasites transmitted by the bites infected female Phlebotominae class flies and it endemic in 102 countries. It seen worldwide, particularly developing In present study, antileishmanial efficacy free rutin nanoparticles formed encapsulating flavonoid polymer nanoparticle system on infantum promastigotes were contrasted. The rutin-loaded PLGA (RT)NPs proliferation promastigote form L. was examined for first time counting vitro activities using MTT assay thoma slide. has been observed that significant affect at concentrations 1000, 750, 500 μg/ml 72nd 96th hours. viability% value decreased 10-fold 1000 concentration (RT)NPs. While IC50 29.2 ± 4.5 specimens treated with RT varied concentrations, found to be 23.0 2.7 µg/ml absorbance measurements lower compared 48th hour.